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USMLE Step 2 is a one-day (8 hours) exam. Similar to the Step 1, the test items are divided into blocks, and test item formats vary within each block, with the total number of exam questions equaling to 355.

Step 1 of the USMLE (United States Medical Licensing Examination) is the first part of the United States Medical Licensing Examination. It is open to medical school student and graduates to assess their ability to apply important concepts fundamental to the practice of medicine. While American medical students usually take USMLE Step 1 at the end of the second year of medical school, all graduates of foreign medical schools must take this exam is they intend to practice medicine in the United States.

Reference: http://www.usmle.org/step-1/#question-formats

USMLE USMLE Exam Syllabus Topics:

SectionObjectives
Gastrointestinal System- Digestive System Disorders
  • 1. Liver Disease
  • 2. Gastrointestinal Pathology
Human Development- Growth and Development
  • 1. Developmental Abnormalities
  • 2. Embryology
Endocrine System- Hormonal Regulation and Disease
  • 1. Adrenal Disorders
  • 2. Pituitary Disorders
  • 3. Thyroid Disorders
Central and Peripheral Nervous Systems- Neurologic Disorders
  • 1. Neuroanatomy
  • 2. Neurologic Diseases
  • 3. Neuropathology
Multisystem Processes and Disorders- Systemic Conditions
  • 1. Nutrition
  • 2. Neoplasia
  • 3. Infectious Diseases
Respiratory System- Pulmonary Medicine
  • 1. Lung Diseases
  • 2. Airway Disorders
Hematopoietic and Lymphoreticular Systems- Blood and Immune Disorders
  • 1. Anemias
  • 2. Coagulation Disorders
  • 3. Leukemias and Lymphomas
Reproductive System- Male and Female Reproductive Health
  • 1. Reproductive Disorders
  • 2. Reproductive Physiology
Renal and Urinary System- Kidney and Urinary Disorders
  • 1. Renal Physiology
  • 2. Renal Pathology
Musculoskeletal System- Bones, Joints, and Muscles
  • 1. Orthopedic Disorders
  • 2. Rheumatologic Diseases
Cardiovascular System- Cardiac and Vascular Disorders
  • 1. Vascular Pathology
  • 2. Heart Disease
Skin and Related Connective Tissue- Dermatologic Conditions
  • 1. Skin Neoplasms
  • 2. Inflammatory Skin Disorders
General Principles- Foundational Medical Sciences
  • 1. Pathology
  • 2. Microbiology
  • 3. Behavioral Sciences
  • 4. Genetics
  • 5. Immunology
  • 6. Pharmacology
  • 7. Biochemistry
  • 8. Physiology

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